General Information

  • ID:  hor002898
  • Uniprot ID:  B3EWK9
  • Protein name:  Neuropeptide Y-amide
  • Gene name:  NA
  • Organism:  Delia radicum (Cabbage root fly) (Anthomyia brassicae)
  • Family:  NA
  • Source:  animal
  • Expression:  Detected in larvae. |Expressed in the CNS and the ring gland but not in midgut, thoracic perisympathetic organs (tPSO) or abdominal perisympathetic organs (aPSO) (at protein level).
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Delia (genus), Anthomyiinae (subfamily), Anthomyiidae (family), Muscoidea (superfamily), Calyptratae, Schizophora, Cyclorrhapha, Eremoneura, Muscomorpha (infraorder), Brachycera (suborder), Diptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  NA

Sequence Information

  • Sequence:  LPSIGHYY
  • Length:  8(1-8)
  • Propeptide:  LPSIGHYY
  • Signal peptide:  NA
  • Modification:  T8 Tyrosine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor002898_AF2.pdbhor002898_ESM.pdb

Physical Information

Mass: 107411 Formula: C46H64N10O12
Absent amino acids: ACDEFKMNQRTVW Common amino acids: Y
pI: 7.53 Basic residues: 1
Polar residues: 4 Hydrophobic residues: 2
Hydrophobicity: -3.75 Boman Index: 244
Half-Life: 5.5 hour Half-Life Yeast: 3 min
Half-Life E.Coli: 2 min Aliphatic Index 97.5
Instability Index: 12725 Extinction Coefficient cystines: 2980
Absorbance 280nm: 425.71

Literature

  • PubMed ID:  22848525
  • Title:  Peptidomics of the Agriculturally Damaging Larval Stage of the Cabbage Root Fly Delia Radicum (Diptera: Anthomyiidae)